5.5.1.1. Categorical outcomes

As we explained before, it is good to discuss the clinical decision threshold and try to determine them on beforehand. However, one must be careful not to apply this in a too mechanical way, as you need also to take into account the downsides of the intervention, such as side effect or morbidity induced by the intervention, on which in a lot of cases you have only information after collecting the evidence. If it is not possible to determine a threshold, then GRADE suggests to use a RRR or RRI greater than 25%. This 25% threshold is a good and pragmatic starting point, but other factors should be taken into account as well, such as the absolute risk reduction.